Grape Seed Extract Supplement Benefit
Hypertension .
Cardiovascular researchers at UC Davis, School of Medicine, completed the first human clinical trial to study the benefits of grape seed extract on patients with high blood pressure. The one month study was done on 24 male and female patients diagnosed with metabolic syndrome, which is a combination of factors that add up to high risk for heart disease, including elevated blood pressure, excess abdominal body weight, high blood cholesterol fats, and high blood sugar. The patients were divided into three groups of eight. The first group received a placebo while the second and third groups received 150 mgs and 300 mgs, respectively, of a grape seed extract developed and made by Polyphenolics, a division of Constellation Wine US. All participants’ blood pressure was automatically measured and recorded for 12 hours after grape see extract ingestion. Participants in the two groups receiving grape seed extract experienced an average drop in systolic pressure or 12 mm and diastolic pressure 8 mm compared to placebo.
Dr. Sahelian says : This is encouraging news regarding the role of grape seed extract and blood pressure. It would seen a good idea to take 100 mg a day of grape seed extract with medical supervision and surveillance of BP.
Skin cancer.
Chemicals found in grape seeds may help ward of skin cancer due to regular exposure to the sun. Researchers from the University of Alabama, Birmingham exposed hairless mice to ultraviolet-light. Some of the mice they fed a standard diet supplemented with grape seed proanthocyanidins, while control mice were fed a standard diet without this supplement. Dietary supplementation with grape seed extract inhibited light-induced carcinogenesis, study. Mice supplemented with grape seed extract had up to 65 fewer skin cancer tumors than control mice did. Moreover, the tumors seen in grape seed extract – supplemented mice were smaller than those seen in the control mice. Grape seed extracts appear to inhibit suppression of the immune system caused by ultraviolet light. Grape seed extract has antioxidant activity, and UV-induced oxidative stress has been linked to the induction of skin cancers.
Availability.
Grape Seed extract is sold in various extract potencies, including 95 percent proanthocyanidins or 95 percent polyphenols.
Grape seed extract side effects, safety, caution, risk.
Grape seed extract side effects have not been reported in the medical literature, but very few human studies have been done. In one study with cancer patients given radiation therapy and grape seed extract 100 mg three times a day orally for 6 months, no major side effects were reported.
Grape Seed Research.
Polyphenolics in grape seeds-biochemistry and functionality.
J Med Food. 2003.
Grape seeds are waste products of the winery and grape juice industry. These seeds contain lipid, protein, carbohydrates, and 5-8 % polyphenols depending on the variety. Polyphenols in grape seeds are mainly flavonoids, including gallic acid, the monomeric flavan-3-ols catechin, epicatechin, gallocatechin, epigallocatechin, and epicatechin 3-O-gallate, and procyanidin dimers, trimers, and more highly polymerized procyanidins. Grape seed extract is known as a powerful antioxidant that protects the body from premature aging, disease, and decay. Grape seeds contains mainly phenols such as proanthocyanidins (oligomeric proanthocyanidins). Scientific studies have shown that the antioxidant power of proanthocyanidins is 20 times greater than vitamin E and 50 times greater than vitamin C. Extensive research suggests that grape seed extract is beneficial in many areas of health because of its antioxidant effect to bond with collagen, promoting youthful skin, cell health, elasticity, and flexibility. Other studies have shown that proanthocyanidins help to protect the body from sun damage, to improve vision, to improve flexibility in joints, arteries, and body tissues such as the heart, and to improve blood circulation by strengthening capillaries, arteries, and veins. The most abundant phenolic compounds are catechins, epicatechin, procyanidin, and some dimers and trimers.
Grape seed extract activates Th1 cells in vitro.
Although flavonoids manifest a diverse range of biological activities, including antitumor and antiviral effects, the molecular mechanisms underlying these activities await elucidation. We hypothesize that the flavonoid constituents of a proprietary grape seed extract that contains procyandins exert significant antiviral and antitumor effects, by inducing production of the Th1-derived cytokine gamma interferon (IFN-gamma) by peripheral blood mononuclear cells) from healthy donors. Our results show that grape seed extract significantly induced the transcription of IFN-gamma mRNA as demonstrated by reverse transcription-PCR but had no effect on the Th2-derived cytokine interleukin-6. The enhancing effect of grape seed extract on IFN-gamma expression was further supported by a concomitant increase in the number of cells with intracytoplasmic IFN-gamma as well as the synthesis and secretion of IFN-gamma. Our results demonstrate that the potentially beneficial immunostimulatory effects of grape seed extract may be mediated through the initiation of IFN-gamma.
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